N-substituted cycloalkyl and polycycloalkyl alpha-substituted Tr

Details N-substituted cycloalkyl and polycycloalkyl alpha-substituted Tr N-substituted cycloalkyl and polycycloalkyl alpha-substituted Tr

1990-12-19

1994-01-11

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540594, 544 49, 544 51, 544 50, 544105, 544143, 544250, 544253, 544284, 544349, 546 84, 546 85, 546111, 546112, 546121, 546122, 546139, 546152, 546201, 546273, 548189, 548248, 548336, 548484, 548455, 548469, 548465, 548427, 5483051, 5483121, C07D20920, C07D20736, C07D40100, C07D41300

Patent

active

052783162

ABSTRACT:
Novel unnatural dipeptoids of .alpha.-substituted Trp-Phe derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further the compounds are antianxiety agents, antiulcer agents, antidepressant agents, and are agents useful for preventing the withdrawal response produced by chronic treatment or use followed by chronic treatment followed by withdrawal from nicotine, diazepam, alcohol, cocaine, caffeine, or opiods. Also disclosed are pharmaceutical compositions and methods of treatment using the dipeptoids as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds to prepare pharmaceutical and diagnostic compositions.

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