N-substituted cycloalkyl and polycycloalkyl .alpha.-substituted

Details N-substituted cycloalkyl and polycycloalkyl .alpha.-substituted N-substituted cycloalkyl and polycycloalkyl .alpha.-substituted

1991-07-12

1993-11-23

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530331, 548253, 548409, 548411, 548469, A61K 3702, C07K 506, C07K 508

Patent

active

052644197

ABSTRACT:
Novel peptoids of .alpha.-substituted Trp derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further the compounds are antianxiety agents and antiulcer agents. They are agents useful for preventing the response to withdrawal from chronic treatment or use of nicotine, diazepam, alcohol, cocaine, caffeine, or opioids. The compounds are also useful in the treatment and/or prevention of panic attacks. Also disclosed are pharmaceutical compositions and methods of treatment using the peptoids as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds to prepare diagnostic compositions.

REFERENCES:
patent: 4757151 (1988-07-01), Horwell
patent: 5010076 (1991-04-01), Waldeck et al.

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