N-substituted benzene sulfonamides

Details N-substituted benzene sulfonamides N-substituted benzene sulfonamides

2007-04-24

2007-04-24

Kifle, Bruck (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S212080, C514S317000, C514S319000, C514S424000, C540S524000, C540S527000, C546S216000

Reexamination Certificate

active

10976746

ABSTRACT:
Disclosed are N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease.In Formula (I), R1, R2, R3, R4, R3′, R10and R11are as described herein. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders using compounds of Formula (I).

REFERENCES:
patent: 5612353 (1997-03-01), Ewing et al.
patent: WO 00/50391 (2000-08-01), None
patent: WO 03/013527 (2003-02-01), None
patent: WO 03/066592 (2003-08-01), None
Seiffert, D. et al: “Presenilin-1 and -2 are molecular targets for gamma-secretase” The Journal of Biological Chemistry, vol. 275, No. 44, 2000, pp. 34086-34091, XP002321207.

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