N-Substituted aziridine-2-carboxylic acid immunostimulant deriva

Details N-Substituted aziridine-2-carboxylic acid immunostimulant deriva N-Substituted aziridine-2-carboxylic acid immunostimulant deriva

1981-02-20

1983-08-09

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260239E, 2603303, 2603309, 542469, 544111, 544335, 546208, 546275, 548232, C07D20322, C07D40112, C07D40312, A61K 31395

Patent

active

043978487

ABSTRACT:
The present invention provides pharmaceutical compositions containing N-substituted aziridine-2-carboxylic acid derivatives of the general formula: ##STR1## wherein X is a carboxyl, a cyano, an alkoxycarbonyl or an optionally substituted carbamoyl radical, R is a hydrogen atom, or an optionally substituted aliphatic hydrocarbon radical or cycloalkyl or cycloalkenyl radical, and R.sub.1 is a hydrogen atom or an alkyl or phenyl radical; and the pharmacologically acceptable salts thereof, in admixture with a pharmaceutical diluent or carrier. The present invention also provides, as new compounds, N-substituted aziridine-2-carboxylic acid derivatives of general formula (I') but with the proviso that when X is a carbamoyl or alkoxycarbonyl radical and R.sub.1 is a hydrogen atom, R is not a methyl, ethyl, isopropyl or benzyl radical; and the pharmacologically acceptable salts thereof, and also provides processes for the preparation of these new compounds. Furthermore, the present invention is concerned with the use of the compounds of general formula (I') and of the pharmacologically acceptable salts thereof for combating diseases associated with a weakening of the immune system.

REFERENCES:
Kostyanovskii et al., Chem. Abs. 85, 192460z (1976).
Kostyanovskii et al, Chem. Abs. 81, 25474t.
Kostyanovskii et al, Chem. Abs. 87, 101491n.

Affiliated with

Also associated with

Rating

N-Substituted aziridine-2-carboxylic acid immunostimulant deriva does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N-Substituted aziridine-2-carboxylic acid immunostimulant deriva, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-Substituted aziridine-2-carboxylic acid immunostimulant deriva will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-586848