N-substituted azaheterocyclic compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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5142328, 514255, 514256, 514275, 514320, 514324, 514326, 514337, 514352, 514365, 514382, 514396, 514422, 514431, 514450, 540553, 544147, 544145, 544375, 544297, 544327, 544326, 546196, 546202, 5462797, 5462817, 546148, 546165, 548518, 5483114, 548250, 548132, 548131, 548202, 548962, 548525, 548527, 549 12, 549354, 549 59, 549 60, C07D33714, C07D491113, C07D21190, A61K 31445

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active

060604689

ABSTRACT:
The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.1a, R.sup.2, R.sup.2a, p, r and s are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to secretion and circulation of insulin antagonising peptides.

REFERENCES:
Valenta et al., Collect. Czech. Chem. Commun., vol. 54, pp. 1403-1421, 1989.
Bartl et al., Collect. Czech. Chem. Commun., vol., 49, pp. 1810-1815, 1984.
Jilek et al., Collect. Czech. Chem. Commun., vol., 53, pp. 2731-2741, 1988.
Abstract--The Abstract No. 183364g, vol., 115, No. 17, p. 935, 1991.
Abstract--The Abstract No. 49722u, vol., 115, No. 5, p. 854, 1991.
Abstract--The Abstract No.57689a, vol. 110, No. 7, p. 696, 1989.
CAS printout of structures of CS 268626, Mar. 14, 1990.

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