N-substituted azaheterocyclic carboxylic acids and esters thereo

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514422, 514320, 546202, 546196, 546103, 546102, 546203, 548524, 540592, 540550, 540479, 544102, 544 31, C07D40506, C07D40906, A61K 31445, A61K 3140

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active

057212546

ABSTRACT:
The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

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patent: 3252984 (1966-05-01), Cusic et al.
patent: 5538986 (1996-07-01), Ting et al.
Andersen et al., J. Med Cem., vol. 36, pp. 1716-1725, 1993.
Nakanishi et a., J. Med Cem., vol. 13, No. 4, pp. 644-48, 1979.

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