N-substituted azaheterocyclic carboxylic acids and esters thereo

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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5142255, 5142298, A61K 31645

Patent

active

061660094

ABSTRACT:
The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

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Chemical Abstracts, vol. 76, No. 23, Jun. 5, 1972, Columbus, OH., p. 460, Abstract No. 140577n, JP, 7204069, A, Nakanishi, Michio et al., Feb. 4, 1972.
Chemical Abstracts, vol. 81, No. 5, Aug. 5, 1974, Columbus, OH., p. 424, Abstract No. 25566z, JP, 7330064, A, Nakanishi, Michio et al., Dec. 23, 1968.
Sindelar et al., Anthistamine Substances. Tricyclic Analogues Of N-(4,4-Diphenyl-3Butene-1-YL)Nipecotic Acid And Some Related Compounds. Collect. Czech. Chem. Commun., 1994, vol. 59, pp. 667-675.

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