N-substituted azaheterocyclic carboxylic acids and esters thereo

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546203, 546204, 548528, 514428, C07D20708, C07D21132, A61K 3140, A61K 31445

Patent

active

057122920

ABSTRACT:
The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

REFERENCES:
patent: 2957870 (1960-10-01), Cusic et al.
patent: 3177211 (1965-04-01), Zenitz et al.
patent: 3480624 (1969-11-01), Fouche et al.
Andersen et al., J. Med. Chem., vol. 36, p. 1716-1725, 1993.
Nakanishi et al., J. Med. Chem., vol. 13, No. 4, pp. 644-648, 1979.

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