N-substituted anilines, inhibitors of phospholipases A.sub.2

Details N-substituted anilines, inhibitors of phospholipases A.sub.2 N-substituted anilines, inhibitors of phospholipases A.sub.2

1992-07-15

1994-06-28

Killos, Paul J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514120, 514121, 514311, 514357, 514510, 514538, 514539, 514562, 514566, 514569, 546172, 546174, 546335, 558 70, 560 12, 560 22, 560 40, 560 41, 560 43, 560 44, 560 45, 562426, 562430, 562433, 562443, 562444, 562448, 562452, 562453, 562456, 562457, A61K 31195, C07C31304, C07C31714, C07D21514

Patent

active

053247477

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, n, m, o, p and q are as hereinafter set forth, and, when R.sub.2 is hydrogen, pharmaceutically acceptable salts thereof with bases, are described. The compounds of formula 1 are potent inhibitors of phospholipases A.sub.2 (PLA.sub.2 's) and are therefore useful in the treatment of inflammatory diseases, such as psosiasis, inflammatory bowel disease, asthma, allergy, arthritis, dermatitis, gout, pulmonary disease, myocardial ischemia/reperfusion, and trauma induced inflammation, such as spinal cord injury.

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R. Y. Tsien, Biochemistry, 19, 2396-2404 (1980).
G. Schwarzenbach, A. Willi and R. O. Bach, Helv. Chim. Acta., 30, 1303-1320 (1947).

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