N-substituted aminoalkanediphosphonic acids

Details N-substituted aminoalkanediphosphonic acids N-substituted aminoalkanediphosphonic acids

1990-02-16

1991-07-30

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 79, 514 85, 514 89, 514 92, 514 94, 514102, 514107, 544243, 544337, 546 22, 546 23, 548112, 548119, 562 13, 562 14, 562 21, A61K 31675, C07F 902

Patent

active

050360582

ABSTRACT:
Compounds of the formula I ##STR1## in which R.sub.1 is an aromatic radical, n is 0, 1, 2 or 3, X is an oxy group, a thio group which can be oxidized or an imino group which is unsubstituted or has aliphatic substituents, alk.sub.1 and alk.sub.2 are identical or different divalent aliphatic radicals, and R.sub.2 is hydrogen or a monovalent aliphatic radical and salts thereof have properties which regulate calcium metabolism and can be employed for the treatment of diseases connected with disturbances in this metabolism. They are prepared, for example, by reacting a compound of the formula ##STR2## in which X.sub.3 is carboxyl with a phosphorylating agent and hydrolysing the primary product.

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patent: 4871720 (1989-10-01), Jaeggi
patent: 4876248 (1989-10-01), Breliere et al.
patent: 4933472 (1990-06-01), Isomura et al.

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