Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1976-05-14
1977-07-12
Rotman, Alan L.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
2602948D, 2602948E, 26032611R, 26032612R, 26032613R, 260315, 2602948C, 260465E, 260470, 260551S, 260574, 260575, 260577, C07D21338, C07D41706
Patent
active
040353753
ABSTRACT:
Preparing ortho-substituted anilines by reacting an N-chloroaniline with a non-carbonylic di-hydrocarbon sulfide to form an azasulfonium chloride, reacting the azasulfonium chloride with a strong base to form an aniline substituted in the 2-position with a hydrocarbon-S-hydrocarbyl thio-ether group. The ortho-substituted thio-ether compounds can be reduced with a de-sulfurizing reducing agent such as Raney nickel or the like to form the orthoalkylated aniline. The analine may be an amino-pyridine. The azasulfonium salt and thio-ether intermediate products can be isolated and recovered. If desired, the thio-ether compounds can be reduced to form ortho-alkylated aniline products which are useful as intermediates for a wide variety of purposes, including their uses in making dyes, herbicides, and the like.
REFERENCES:
kharasch, Organic Sulfur Compounds, vol. 1, Pergamon Press (1961).
Kharasch, Organic Sulfur Compounds, vol. II, Pergamon Press (1966).
Gassman et al., Tetrahedron Letters, No. 6, Pergamon Press, pp. 497-500, (Feb. 1972).
Gassman Paul G.
Gruetzmacher Gordon D.
Hueschen Gordon W.
Rotman Alan L.
The Ohio State University Research Foundation
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