N-Substituted amino glycoside compounds, their production, and t

Details N-Substituted amino glycoside compounds, their production, and t N-Substituted amino glycoside compounds, their production, and t

1978-02-24

1980-04-22

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 10, 536 17R, A61K 3171, C07H 1522

Patent

active

041995724

ABSTRACT:
The invention relates to new derivatives, substituted on one or more nitrogen atoms, of 4,6-di-(amino-glycosyl)-1,3-diamino-cyclitols, which include the gentamycins, sisomicin, verdamycin, tobramycin, the kanamycins, the antibiotics G-418, 66-40 B, 66-40 D, JI-20 B, JI-20 B and G-52, and the 5-epi-, 5-epi-amino-5-deoxy and 5-epi-azido-5-deoxy derivatives of these antibiotics and the metamycins, and furthermore to processes for the preparation of these derivatives and to pharmaceutical compositions which contain the derivatives of the above mentioned 4,6-di-(amino-glycosyl)-1,3-diamino-cyclitols or their pharmaceutically acceptable acid addition salts, and to their use as antibacterial agents.

REFERENCES:
patent: 3920628 (1975-11-01), Daniels
patent: 4002608 (1977-01-01), Wright et al.
patent: 4002742 (1977-01-01), Wright et al.
patent: 4062947 (1977-12-01), Wright et al.
patent: 4085208 (1978-04-01), Mallams et al.

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