N-substituted amino acids as intermediates in the preparation of

Details N-substituted amino acids as intermediates in the preparation of N-substituted amino acids as intermediates in the preparation of

1982-06-08

1985-07-30

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

546 2, 546 5, 546 6, 546 84, 546113, 546114, 546145, 546164, 546258, 560 22, 560 39, 560 40, 562443, 562444, 562449, C07C10384

Patent

active

045323429

ABSTRACT:
N-substituted amino acids are described which when coupled with 1,2,3,4-tetrahydroisoquinolines result in substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids as anti-hypertensive agents. The novel intermediates are in turn prepared by reacting an amino acid such as alanine with 2-bromo-4-phenyl butanoic acid or an ester thereof.

REFERENCES:
patent: 3691169 (1972-09-01), Gray
patent: 3929830 (1975-12-01), Richter et al.
patent: 4046889 (1977-09-01), Ondetti et al.
patent: 4052511 (1977-10-01), Cushman et al.
patent: 4086338 (1978-04-01), Cushman et al.
patent: 4091024 (1978-05-01), Ondetti et al.
patent: 4105776 (1978-08-01), Ondetti et al.
patent: 4105789 (1978-08-01), Ondetti et al.
patent: 4116962 (1978-09-01), Ondetti et al.
patent: 4125604 (1978-11-01), Okamoto et al.
patent: 4128653 (1978-12-01), Cushman et al.
patent: 4129566 (1978-12-01), Ondetti et al.
patent: 4140864 (1979-02-01), Ondetti et al.
patent: 4146084 (1979-05-01), Ondetti et al.
patent: 4154840 (1979-05-01), Ondetti et al.
patent: 4154935 (1979-05-01), Ondetti et al.
patent: 4154936 (1979-05-01), Ondetti et al.
patent: 4154942 (1979-05-01), Ondetti et al.
patent: 4251444 (1981-02-01), Freed et al.
patent: 4256751 (1981-03-01), Hayashi et al.
patent: 4350704 (1982-09-01), Hoefle et al.
patent: 4404206 (1983-09-01), Vincent et al.
Morrison, et al., Organic Chemistry, 2nd Ed., 1966, Allyn and Bacon, Inc., Boston, pp. 733-734.
Patchett et al., "Nature", vol. 288, 1980, pp. 280-283.
Hoefle, et al., "Chemical Abstracts", vol. 96, 1982, col. 96: 122630h.
Hoefle, et al., "Chemical Abstracts", vol. 97, 1982, col. 97: 72257q.
Geiger, et al., "Chemical Abstracts", vol. 97, 1982, col. 92759h.
Neustadt, et al., "Chemical Abstracts", vol. 97, 1982, col. 97: 216730p.
Blankley, "Chemical Abstracts", vol. 98, 1983, col. 98: 54484c.
Kaltenbronn, et al., "Chemical Abstracts", vol. 98, 1983, col. 98: 143072j.

Affiliated with

Also associated with

Rating

N-substituted amino acids as intermediates in the preparation of does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N-substituted amino acids as intermediates in the preparation of, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-substituted amino acids as intermediates in the preparation of will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2374215