N-substituted-7,8-dihydroxycyclopentano[f]-1,2,3,4-te trahydrois

Details N-substituted-7,8-dihydroxycyclopentano[f]-1,2,3,4-te trahydrois N-substituted-7,8-dihydroxycyclopentano[f]-1,2,3,4-te trahydrois

1974-03-28

1976-05-04

Narcavage, Joseph A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260286R, 260286Q, 260289C, 2602835Y, 2605705CA, 260599, 260645, 260668F, 424258, C07D21718, C07D21706, C07D21716

Patent

active

039547744

ABSTRACT:
N-substituted cyclopentano[f]-1,2,3,4-tetrahydroisoquinolines of the formula ##SPC1##
Wherein R.sub.1 and R.sub.2 represent hydroxy, lower alkoxy, lower alkanoyloxy or aryl-lower alkanoyl groups, R.sub.3 represents hydrogen or a lower alkyl group and R.sub.4 represents a lower alkyl, arylcarbonyl, aryl-lower alkyl, benzhydryl-lower alkyl, lower alkanoyl, aryl-lower alkanoyl, benzhydryl-lower alkanoyl or benzhydrylcarbonyl group, and acid addition salts and quaternary ammonium salts thereof, and pharmaceutical compositions containing one or more of the compounds useful for lowering blood pressure in animals.

REFERENCES:
patent: 1942108 (1934-01-01), Laska et al.
patent: 3318896 (1967-05-01), Pribyl et al.
patent: 3567733 (1971-03-01), Nomine et al.
Burger, "Medicinal Chemistry," pp. 42, 497.

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