N-(substituted)-[7-(2-cyanoacetamido)cephalosporanic]amide deriv

Details N-(substituted)-[7-(2-cyanoacetamido)cephalosporanic]amide deriv N-(substituted)-[7-(2-cyanoacetamido)cephalosporanic]amide deriv

1986-05-19

1988-07-19

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514202, 514204, 540223, 540226, 540227, A61K 31545, C07D50126, C07D50136, C07D50122

Patent

active

047585587

ABSTRACT:
Disclosed herein are the derivatives of substituted cephalosporanic acid represented by the formula (I): ##STR1## wherein R.sup.1 represents a 4-pyridylthiomethyl group, an alpha-aminobenzyl group, a cyanomethyl group or a 1-tetrazolylmethyl group; R.sup.2 represents a hydrogen atom, an acetoxy group or a (5-methyl-1,3,4-thiadiazol-2-yl)thio group; R.sup.3 represents a hydrogen atom, a hydroxyl group, a carbamoyl group, an alkyl group having 1 to 4 carbon atoms or --(CONH).sub.m (CH.sub.2).sub.n --COOH wherein m is 0 or 1, n is 0, 1 or 2 and the carboxyl group may have been converted to a salt or an ester thereof; p is 0, 1 or 2 and X represents carbon atom or nitrogen atom, and antibiotics comprising the derivatives of substituted cephalosporanic acid represented by the formula (I).

REFERENCES:
patent: 3124576 (1964-03-01), Stedman
patent: 3338897 (1967-08-01), Takano et al.
patent: 3483197 (1969-12-01), Bickel et al.
patent: 3641015 (1972-02-01), Lewis et al.
patent: 4045437 (1977-08-01), Barth
patent: 4496561 (1985-01-01), Muto et al.
Greene, Theodora, Protective Groups in Organic Synthesis, John Wiley, New York (1981) p. 182.

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