N-Substituted-6,8-dioxamorphinans

Details N-Substituted-6,8-dioxamorphinans N-Substituted-6,8-dioxamorphinans

1975-10-28

1977-04-05

Todd, G. Thomas

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26029355, 260DIG13, 424267, C07D22126

Patent

active

040161676

ABSTRACT:
N-substituted-6,8-dioxamorphinans have been found to possess potent narcotic agonist and/or antagonist activity. For example, the compound 17-cyclopropylmethyl-7,7-dimethyl-3-hydroxy-6,8-dioxamorphinan has been found to possess potent agonist-antagonist activity. These compounds are prepared by total synthesis and are not derived from opium alkaloids.

REFERENCES:
patent: 3853889 (1974-12-01), Monkovic et al.
patent: 3891657 (1975-06-01), Monkovic et al.
patent: 3910920 (1975-10-01), Menard et al.
May et al., J. Org. Chem. 26, 188-193 (1961).
Kugita et al., J. Org. Chem. 26, 1954-1957 (1961).
Murphy et al., J. Org. Chem. 25, 1386-1388 (1960).
Chignell et al., J. Med. Chem. 8, 235-238 (1965).
Saito et al., J. Org. Chem. 26, 4536-4540 (1961).
Eddy et al., "Synthetic Analgesics, Part IIB," Pergamon Press, New York, pp. 115-182.

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