N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and

Details N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and

1991-02-04

1991-07-09

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544368, 546199, 548241, C07D41314, A61K 31445

Patent

active

050306391

ABSTRACT:
There are disclosed compounds having the formula ##STR1## wherein R.sub.1 is hydrogen or loweralkyl; R.sub.2 is loweralkyl, arylloweralkyl, diarylloweralkyl or --CH.sub.2 CHOHCH.sub.2 OR.sub.5, R.sub.5 being aryl, or alternatively --NR.sub.1 R.sub.2 taken together is ##STR2## or ##STR3## R.sub.6 being aryl, arylloweralkyl, diarylloweralkyl, ##STR4## or ##STR5## and R.sub.3 and R.sub.4 are each independently methoxy or hydroxy, which compounds are useful as analgesic and hypotensive agents.

REFERENCES:
patent: 4291042 (1981-09-01), Ward
patent: 4390544 (1983-06-01), Davis et al.
patent: 4397853 (1983-08-01), Kawakita et al.
patent: 4980365 (1990-12-01), Davis
patent: 5008264 (1991-04-01), Davis

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