Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1974-03-28
1976-06-08
Rush, Raymond V.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260240G, 260286R, 260286Q, 260289C, 2605705CA, 260591, 260599, 260611F, 260617F, 424258, C07D21716, C07D21718
Patent
active
039622541
ABSTRACT:
N-substituted cyclopentano[h]-1,2,3,4-tetrahydroisoquinolines of the formula ##SPC1##
Wherein R and R.sub.1 represent hydroxy, lower alkoxy, lower akanoyloxy or aryl-lower alkanoyloxy groups, R.sub.3 represents hydrogen or a lower alkyl group and R.sub.4 represents a lower alkyl, arylcarbonyl, aryl-lower alkyl, benzhydryl-lower alkyl, lower alkanoyl, aryl-lower alkanoyl, benzhydryl-lower akanoyl or benzhydrylcarbonyl group, and acid addition salts and quaternary ammonium salts thereof, and pharmaceutical compositions containing the compounds useful for lowering blood pressure in animals.
REFERENCES:
patent: 1942108 (1934-01-01), Laska et al.
patent: 3282943 (1966-11-01), Landgraf et al.
patent: 3318896 (1967-05-01), Pribyl et al.
patent: 3567733 (1971-03-01), Nomine et al.
patent: 3798225 (1974-03-01), Kreighbaum
Burger, "Medicinal Chemistry," pp. 42, 497.
House, "Modern Synthetic Reactions," 1965 p. 34.
Morrison et al., "Organic Chemistry," 1966 pp. 473-475.
March, "Advanced Organic Chemistry," 1968 p. 414.
Jones Raymond Henry
Mathison Ian William
Solomons William Ebenezer
Marion Laboratories, Inc.
Rush Raymond V.
Wheeler David E.
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