N-substituted 4-aminopteridines, synthesis and use thereof...

Details N-substituted 4-aminopteridines, synthesis and use thereof... N-substituted 4-aminopteridines, synthesis and use thereof...

2005-01-18

2005-01-18

Raymond, Richard L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S260000

Reexamination Certificate

active

06844343

ABSTRACT:
Compounds of formula (I), where preferably: A=a bridge of partial formula (II) or (III), R1and R2=independently (substituted) alkyl, aryl or aralkyl, or together form a heterocycle, R3=H, —CO-Alkyl, or —CO-Aryl, R4=Aryl, —CO—O-Aryl or —CO-Aryl and R5=H, are potent inhibitors of NO-synthase and are suitable as pharmaceutical agents of prophylaxis and treatment of disease states associates with a disturbed NO metabolism.

REFERENCES:
patent: 5459158 (1995-10-01), Moore et al.
patent: 5902810 (1999-05-01), Pfleiderer et al.
patent: 41 20 247 (1992-12-01), None
patent: 4120247 A 1 (1992-12-01), None
patent: 44 18 096 (1995-11-01), None
patent: 44 18 097 (1995-11-01), None
patent: 0 906 913 (1999-04-01), None
patent: 0906913 (1999-04-01), None
patent: WO 94 14780 (1994-07-01), None
patent: WO 9532203 (1995-11-01), None
patent: WO 00 39129 (2000-07-01), None
Froehlich et al., Chemical Abstracts, vol. 131:317316, 1999.*
S. Taghavi-Moghadam et al., “A New, General and Regioselective Method for the Synthesis of 2,6 Disubstituted 4-Aminopteridines”,Tetrahedran Letters, 38(39), pp. 6835-6836 (1997).
U.S. patent application No. 60/113,989, filed Dec. 28, 1998, which is the priority document of WO 00 39129.
Ph.D. Thesis of S. Taghavi-Moghadam, Dec. 1996.
PCT Search Report of Jan. 23, 2001.
Derwent Abstract of EP 0 906 913A, 1999.
Derwent Abstract of DE 44 18 097 A, 1995.
Derwent Abstract of DE 41 20 247 A, 1992.

Affiliated with

Also associated with

Rating

N-substituted 4-aminopteridines, synthesis and use thereof... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N-substituted 4-aminopteridines, synthesis and use thereof..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-substituted 4-aminopteridines, synthesis and use thereof... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3366565