N-substituted-17.beta.-carbamoylandrost-4-en-3-one 5.alpha. redu

Details N-substituted-17.beta.-carbamoylandrost-4-en-3-one 5.alpha. redu N-substituted-17.beta.-carbamoylandrost-4-en-3-one 5.alpha. redu

1978-04-13

1980-03-04

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2603971, 2602395, A61K 3156, C07J 900

Patent

active

041917596

ABSTRACT:
Amides of 17.beta.-carboxy-4-androsten-3-one having the formula: ##STR1## where R.sup.1 and R.sup.2 are hydrogen (only one may be hydrogen), C.sub.1-4 alkyl, cyclo C.sub.5-6 alkyl, phenyl, or together with the nitrogen are a 5 or 6 membered heterocycle with up to one other heteroatom selected from oxygen and nitrogen; R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are hydrogen or C.sub.1-3 alkyl; R.sup.7 is hydrogen or cyano; Z is oxygen, N-R.sup.8 where R.sup.8 is C.sub.1-3 alkyl, or CH--R.sup.9 where R.sup.9 is hydrogen, .alpha.-fluoro, or .alpha.-C.sub.1-3 alkyl,

REFERENCES:
patent: 3917829 (1975-11-01), Voight et al.
patent: 4088760 (1978-05-01), Benson et al.
Barber et al., "J. Org. Chem.", 19, (1954) pp. 1758-1765.

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