N.sub.b -Quaternary derivatives of sandwicine and isosandwicine

Details N.sub.b -Quaternary derivatives of sandwicine and isosandwicine N.sub.b -Quaternary derivatives of sandwicine and isosandwicine

1984-05-31

1985-11-12

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514279, 514281, 544125, 546 40, 546 43, A61K 31435, C07D45500, C07D47108

Patent

active

045528772

ABSTRACT:
New N.sub.b -quaternary 10-bromosandwicine and 10-bromoisosandwicine derivatives are disclosed which exhibit antiarrhythmic properties and adrenolytic properties and which have the formula I ##STR1## wherein R represents a carbon-attached organic group containing 1 to 10 carbon atoms and A.sup..crclbar. represents an acid anion, as well as pharmaceutical formulations thereof and processes and intermediates for their preparation.

REFERENCES:
Petter et al., "The Antifibrillatory Effect on the Heat of Ajmaline, Bromo-Ajmaline, Quinidine and Novocainamide" (1962).
Volkner et al., "Ueber die Herzwirkung von Ajmalindervaten bei Kanlnchen, Beurteilt an der Veraenderung der QUR-Komplexe" (1982).

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