N.sub.b Quaternary derivatives of ajmaline and isoajmaline, meth

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514279, 514281, 544125, 546 40, 546 43, A61K 31435, C07D45500, C07D47108

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active

045542740

ABSTRACT:
New quaternary derivatives of 10-bromoajmaline and 10-bromoisoajmaline are disclosed which exhibit antiarrhythmic and adrenolytic properties and which have the formula I ##STR1## wherein R represents a carbon-attached organic group containing 1 to 10 carbon atoms and A.sup.- represents an acid anion as well as pharmaceutical formulations thereof and processes and intermediates for their preparation.

REFERENCES:
Petter et al., "The Antifibrillatory Effect on the Heart of Ajmaline, Bromo-Ajmaline, Quinidine and Novocainamide", (1962).

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