N.sub..alpha. -2-(4-Nitrophenylsulfonyl) ethoxycarbonyl-amino ac

Details N.sub..alpha. -2-(4-Nitrophenylsulfonyl) ethoxycarbonyl-amino ac N.sub..alpha. -2-(4-Nitrophenylsulfonyl) ethoxycarbonyl-amino ac

1996-02-01

1997-04-01

Barts, Samuel

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560 13, 549390, 5483385, 548495, C07C31500

Patent

active

056167881

ABSTRACT:
Protected amino acid derivatives of the general formula ##STR1## wherein R.sub.1 represents hydrogen atom, and R.sub.2 represents hydrogen, methyl, isopropyl, 1-methylpropyl, 2-methylpropyl, tert-butoxymethyl, 1-tert-butoxyethyl, 2-methylthioethyl, benzyl, carboxamidomethyl, 2-carboxamidoethyl, tert-butoxycarbonylmethyl, 2-(tert-butoxycarbonyl)ethyl, 4-(tert-butoxycarbamido)butyl, 4-tert-butoxybenzyl, indolyl-3-methyl, S-(triphenylmethyl)thiomethyl, 1-(triphenylmethyl)imidazolyl-4-methyl, 3-(N.sup.G -mesitylenesulfonyl)guanidinopropyl, N-xanthylcarboxamidomethyl, 2-(N-xanthylcarboxamido)ethyl or S-(acetamidomethyl)thiomethyl; or R.sub.1 and R.sub.2 together represent propylene radical. Methods for the preparation of said derivatives are provided, and a process for solid phase peptide synthesis using said derivatives is described.

REFERENCES:
Smukov, V.V., Tetrahedron Letters, vol. 35, No. 42 p. 7821-7824 (1994) (Exhibit 1) Oct. 17, 1994.
Chem Abstracts 115:72199, Schielen et al Date 1991.

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