N.sub.3 S.sub.2 chelating ligands optionally radiolabelled with

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 149, 424 165, 534 10, 534 14, 530311, 540450, 564368, A61K 5100, A61M 3614

Patent

active

056329695

ABSTRACT:
Novel N.sub.3 S.sub.2 chelating ligands can be chelated to a radiodetectable element, Tc or Re, and are useful for radiolabeling peptides. A group of peptides especially useful are somatostatin derivatives which are valuable of the selective detection or treatment of tumors with somatostatin receptors.

REFERENCES:
patent: 4837303 (1989-06-01), Jung
patent: 4986979 (1991-01-01), Morgan et al.
patent: 5071636 (1991-12-01), Yamauchi et al.
patent: 5101041 (1992-03-01), Troutner et al.
patent: 5395608 (1995-03-01), Troutner et al.
patent: 5405601 (1995-04-01), Dunn et al.
patent: 5443815 (1995-08-01), Dean et al.
patent: 5556939 (1996-09-01), Flanagan et al.
Serratrice et al (1994), J. Chim. Phys., vol. 91, pp. 753-760 "Paramagnetic Copper (II) and Diamagnetic Copper (I) Complexes with N.sub.3 S.sub.2 and N.sub.2 S.sub.2 Ligands: an EPR and .sup.1 H NMR Study".
DeWanjer (1990), Seminars in Nuclear Medicine, vol. 20, No. 1, pp. 5-27, "The Chemistry of 99m-Tc-Labeled Radio Pharmaceuticals".
Biniakiewicz et al (1992), J. Med. Chem., vol. 35, pp. 274-279 "A New, General Synthetic Route to Multidentate N.sub.1 S Ligands for Use in Technetium-99m Radio-Pharmaceuticals, Preparation of Diamido Disulfur, Diamino Dithiol, and Tripodal N.sub.3 S.sub.3 Prototypes. Comparative Biodistributions of [99m Tc.sup.v O-DADS].sup.- Analgos Which Contain 5,5,5- and 5,7,5-Membered Chelate Ring Systems".
John et al. (1993), Nucl. Med. Bio., vol. 20, No. 2, pp. 217-213, "Synthesis and Biological Evaluation of Gallium Polyaminothiols (PAT)".
Lawrence et al (1991), Aust. J. Chem, vol. 44, pp. 113-121, Quinquedentate Coordination of 6-Methyl-1,1,1-Dithia-4,8-Diazacyclotetradecan-6-Amine to Cobalt (III). X-ray Crystal Structure of the [Co(N.sub.3 S.sub.2)(OOCH.sub.3)] (ClO.sub.4).sub.2 -H.sub.2 O Complex.
Kallert and Mattes (1991), Inorganica Chimica Acta, vol. 180, pp. 263-269, "Xray Crystals Structures of the Copper (II), Nickel (II), and Silver (I) Complexes of a 17-Membered Dibenzo Macrocycle With a N.sub.3 S.sub.2 Donor Set".
Gimarc (1985), Inorganic Chimica Acta, vol. 102, pp. 105-112, "Sulfur-Nitrogen Rings: Relative Stabilities and Structures".
Reubi, J.C., et al., Cancer Research, 47, pp. 5758-5764, Nov. 1, 1987.
Spanevello, R.A., et al., Tetra. Letters, vol. 32, pp. 4675-4678, 1991.
Holum, "Elements of General, Organic, and Biological Chemistry", 9th Edition, p. 257. 1994.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

N.sub.3 S.sub.2 chelating ligands optionally radiolabelled with does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N.sub.3 S.sub.2 chelating ligands optionally radiolabelled with , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N.sub.3 S.sub.2 chelating ligands optionally radiolabelled with will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2327085

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.