Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1980-07-08
1981-05-26
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
546 44, A61K 31485, C07D48902
Patent
active
042698430
ABSTRACT:
Novel N-sec-alkyl derivatives of norcodeine and normorphine wherein the sec-alkyl group contains either four or five carbon atoms. Specifically included are those derivatives of norcodeine and normorphine wherein the sec-alkyl group is 2-butyl, 3-pentyl, .alpha.-methylallyl and .alpha.-methylcyclopropylmethyl. The normorphine derivatives having strong agonist potency combined with strong antagonist qualities and indicated low addiction potential. The norcodeine analogs are useful as intermediates in preparing the corresponding normorphine compounds.
REFERENCES:
patent: 2741609 (1956-04-01), Weijlard
patent: 2741614 (1956-04-01), Clark
patent: 3393197 (1968-07-01), Pachter et al.
patent: 3468891 (1969-09-01), Bartels-Keith et al.
patent: 3676557 (1972-07-01), Lachman et al.
Clark et al., J. Am. Chem. Soc. v. 75, pp. 4963-4966 (1953).
Winter et al., Arch. Int. Pharmacodyn, CX No. 2-3, pp. 186-202 (1957).
Loew et al., Opiates Endog. Opiod. Pept. Proc. Int. Narc. Res. Club Meet, 1976, pp. 399-402, abstract CA, v. 87, 127012g.
De Graw et al., J. Med. Chem. 21, pp. 415-422 (1978).
Uyeno et al., Proc. West, Pharmacol. Soc. 1978, 21, pp. 357-360, Chemical Abstracts, vol. 90, 97480a.
De Graw Joseph I.
Johnson Howard L.
Lawson John A.
Loew Gilda H.
Daus Donald G.
De Witt Donovan J.
Rivers Diana G.
SRI - International
The Board of Trustees of Leland Stanford Jr. University
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