Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1997-06-17
2000-12-19
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514269, 544243, 544319, A61K 31513, C07D23936
Patent
active
06162800&
ABSTRACT:
Disclosed are compounds, compositions and methods for inhibiting interleukin-1.beta. (IL-.beta.) protease activity. The compounds, N-(pyrimidinyl)-aspartic acid .alpha.-substituted methyl ketones and aspartic acid aldehydes, have the formula (I) set out herein. These compounds are inhibitors of 1.beta.-converting enzyme and as such are useful whenever such inhibition is desired. For example, they may be used as research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which 1L-.beta. protease activity is implicated.
REFERENCES:
patent: 5441960 (1995-08-01), Bernstein et al.
patent: 5670494 (1997-09-01), Dolle et al.
Bernstein et al, Chem Abstracts vol. 119, No. 72617 (1993).
Bernstein et al, Chem Abstracts vol. 120, No. 217713 (1994).
Veale et al J. Med. Chem 38 pp. 98-108 (1995).
Miller et al, The Lancet vol. 341 pp. 146-148 (1993).
Cominelli et al, J. Clin. Invest. 86 pp. 972-980 (1990).
Schwab et al, Infect. Immun. 59, pp. 4436-4442 (1991).
Estrov et al, Blood vol. 78, pp. 1476-1484 (1991).
Estrov et al, Blood vol. 79 pp. 1938-1945 (1992).
Medline Abstract for Annals of the Academy of Medicine, 27(5), pp. 738-743, 1998.
Chaturvedula Prasad V.
Dolle Roland E.
Prouty Catherine P.
Schmidt Stanley J.
Dixon Lisa A.
Haley James F.
Raymond Richard L.
Vertex Pharmaceuticals Incorporated
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