N-phosphonylmethoxyalkyl derivatives of pyrimidine and purine ba

Details N-phosphonylmethoxyalkyl derivatives of pyrimidine and purine ba N-phosphonylmethoxyalkyl derivatives of pyrimidine and purine ba

1987-07-17

1992-08-25

Rivers, Diana

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544244, C07F 96561, C07F 9645, A61K 31675

Patent

active

051420511

ABSTRACT:
This invention relates to new nucleotide analogues and solves the technical problem of their use as biologically active compounds. The subject of this invention are N-(2-phosphonylmethoxyethyl) and N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of pyrimidine and purine bases, easily accessible from heterocyclic bases andd their N-(2-hydroxyethyl) or N-(2,3-dihydroxypropyl) derivatives. Some of the compounds, according to this invention, exhibit a marked antiviral activity or can be converted into such active compounds by chemical transformations.

REFERENCES:
patent: 4287188 (1981-09-01), Schaeffer
patent: 4590269 (1986-05-01), Prisbe et al.
patent: 4659825 (1987-04-01), Holy et al.
patent: 4670424 (1987-06-01), MacCoss et al.
patent: 4724233 (1988-02-01), De Clercq et al.
patent: 4808716 (1989-02-01), Holy et al.
Holy, et al., Nucleic Acids Research, Symposium Series No. 14, 1984, pp. 277-278.
De Clercq, et al., Nature, vol. 323, pp. 464-467 (Oct. 2, 1986).

Affiliated with

Also associated with

Rating

N-phosphonylmethoxyalkyl derivatives of pyrimidine and purine ba does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N-phosphonylmethoxyalkyl derivatives of pyrimidine and purine ba, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-phosphonylmethoxyalkyl derivatives of pyrimidine and purine ba will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-386068