N-phenylpyrrole guanidine derivatives as melanocortin...

Details N-phenylpyrrole guanidine derivatives as melanocortin... N-phenylpyrrole guanidine derivatives as melanocortin...

2007-03-06

2007-03-06

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S561000, C534S738000

Reexamination Certificate

active

10484444

ABSTRACT:
The present invention provides novel compounds of the general Formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system:wherein X is (CH2)nwhere n is 0, 1 or 2;R1, R2, R3, R4and R5may be the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, alkoxy having 1 to 5 carbon atoms, hydroxy, alkylsulphonyloxy, cyano, nitro, trihaloalkyl, sulpho or one of the structures given in Scheme 1; or two of R1, R2, R3, R4and R5may together form a methylenedioxy or ethylenedioxy moiety;R6, R7, R8and R9are the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, alkoxy having 1 to 5 carbon atoms, hydroxy, amines (primary, secondary or tertiary) having 0, 1 or 2 carbon atoms, cyano, nitro, trihaloalkyl, amide or sulpho, and z where shown represents the point of attachment of the residue to the phenyl or pyrrole ring;and the pharmacologically active salts thereof.

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Garuti, L., et al., “Amidinoidrazoni di formilesteri e formiltioesteri con substrati N-eterociclici aromatici,” Farmaco, Edizione Scientifica, vol. 36(9), pp. 779-784 (Sep. 1981); English Summary at p. 779, lines 4-5; p. 780 (compound (I)).
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