Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-09-30
2009-12-08
Oh, Taylor Victor (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S132000, C548S250000, C548S128000, C514S381000
Reexamination Certificate
active
07629369
ABSTRACT:
An N-phenylarylsulfonylamide compound of formula (I)(R1is COOH etc.; R2is hydrogen, methyl, etc.; R3and R4are a combination of methyl and methyl, etc.; R5is isopropyl etc.; Ar is thiazolyl, pyridyl, 5-methyl-2-furyl each optionally substituted with methyl; n is zero or 1), a synthetic intermediate for the compound and a process for its preparation. The compound of formula (I) binds to a prostaglandin E2receptor, especially an EP1subtype receptor, and antagonizes it. It is less affected by protein binding, so it has a satisfactory in vivo activity. Therefore, it is considered to be useful as an analgesic, an antipyretic agent, an agent for the treatment of pollakiuria (frequent urination) and/or lower urinary tract disease syndrome or an antineoplastic agent.
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European Search Report dated Nov. 7, 2006.
Hashimoto Shinsuke
Kobayashi Kaoru
Maruyama Takayuki
Naganawa Atsushi
Nakai Yoshihiko
Oh Taylor Victor
Ono Pharmaceuticals Co. Ltd.
Sughrue & Mion, PLLC
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