N-phenylarylsulfonamide compound, pharmaceutical composition...

Details N-phenylarylsulfonamide compound, pharmaceutical composition... N-phenylarylsulfonamide compound, pharmaceutical composition...

2007-06-26

2007-06-26

Oh, Taylor Victor (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S365000

Reexamination Certificate

active

10471673

ABSTRACT:
An N-phenylarylsulfonylamide compound of formula (I)(R1is COOH etc.; R2is hydrogen, methyl, etc.; R3and R4are a combination of methyl and methyl, etc.; R5is isopropyl etc.; Ar is thiazolyl, pyridyl, 5-methyl-2-furyl each optionally substituted with methyl; n is zero or 1), a synthetic intermediate for the compound and a process for its preparation. The compound of formula (I) binds to a prostaglandin E2receptor, especially an EP1subtype receptor, and antagonizes it. It is less affected by protein binding, so it has a satisfactory in vivo activity. Therefore, it is considered to be useful as an analgesic, an antipyretic agent, an agent for the treatment of pollakiuria (frequent urination) and/or lower urinary tract disease syndrome or an antineoplastic agent.

REFERENCES:
patent: 4066636 (1978-01-01), Sera et al.
patent: 615660 (1980-02-01), None
patent: 947500 (1999-10-01), None
patent: 50-117711 (1975-09-01), None
patent: 52-93469 (1980-11-01), None
patent: WO 98/27053 (1998-06-01), None
patent: WO 00/69465 (2000-11-01), None
patent: WO 02/072145 (2002-09-01), None

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