N-[phenyl (piperidin-2-yl) methyl]benzamide derivatives,...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C544S126000, C546S186000, C546S207000, C546S234000

Reexamination Certificate

active

11045247

ABSTRACT:
This invention discloses and claims a compound of general formula (I)in which R1represents either a hydrogen atom, or an optionally substituted alkyl group, or a cycloalkylalkyl group, or an optionally substituted phenylalkyl group, or an alkenyl group, X represents a hydrogen atom or one or more substituents chosen from halogen atoms and trifluoromethyl, alkyl and alkoxy groups, R2represents one or more substituents chosen from halogen atoms, optionally substituted alkoxy and optionally substituted amino. The compounds of this invention exhibit therapeutic utility.

REFERENCES:
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patent: 0499995 (1992-08-01), None
patent: WO 99/45011 (1999-09-01), None
Caulfield et al., J. Med. Chem., 2001, 44, 2679-2682.
Daneman et al., Cell, 2005, 123, 9-12.
LeBowitz, PNAS, 2005, 102, 14485-14486.
Optical Isomers, Newton BBS, Jan. 23, 2006, Newton.dep.anl.gov.
Woods et al. “Method of treating schizophrenia prodrome” CA 145:432223 (2006).
Olivier Froelich et al., Asymmetric Synthesis. 39. Synthesis of 2-(1-Aminoalkyl)piperidines via 2-Cyano-6-phenyl Oxazolopiperidine, Journal of Org. Chem. (1996, pp. 6700-6705, vol. 61).

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