Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-05-11
2000-10-03
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514212, 5142242, 5142278, 5142305, 5142358, 514252, 514253, 514254, 540598, 544 52, 544 584, 544105, 544121, 544295, 544357, 544360, 544361, 544363, 544364, A61K 31496, C07D40112, C07D41704, C07D41712
Patent
active
061273570
ABSTRACT:
Piperazine derivatives of formula I ##STR1## and their pharmaceutically acceptable acid addition salts are 5-HT.sub.1A binding agents, particularly 5-HT.sub.1A antagonists and may be used, for example, as anxiolytics. In the formula A is C.sub.2-4 alkylene chain optionally substituted by lower alkyl, Z is oxygen or sulphur, R is hydrogen or lower alkyl, R.sup.1 is a mono or bicyclic aryl or heteroaryl radical, R.sup.2 is a mono or bicyclic heteroaryl radical and R.sup.3 is hydrogen or a specified radical such as lower alkyl, cycloalkyl, aryl, heteroaryl or optionally substituted amino.
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Cliffe Ian Anthony
Mansell Howard Langham
Barrett Rebecca R.
Bernhardt Emily
John Wyeth & Brother Ltd.
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