N-Phenoxyalkylpiperidine derivatives

Details N-Phenoxyalkylpiperidine derivatives N-Phenoxyalkylpiperidine derivatives

1980-09-10

1982-09-07

Milestone, Norma S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424264, 546210, 546194, 546223, 546224, 546230, 546233, 546234, A61K 31445, A61K 31455, C07D21158, C07D40912, C07D40712, C07D40312

Patent

active

043484018

ABSTRACT:
An N-phenoxyalkylpiperidine derivative of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, an acyl radical or an optionally substituted aryl radical, R.sub.2 is a hydroxymethyl radical, a cyano group, an amidino group, an amidino group substituted by hydroxyl, a 1H tetrazol-5-yl radical or a --CO--R.sub.3 radical, R.sub.3 is a hydroxyl group, a lower alkoxy radical, an amino group, or an amino group substituted by a 1H-tetrazol-5-yl radical, X is an imino group or an oxymethyl radical, A is an alkylene radical containing 2 to 4 carbon atoms, and B is a valency bond or a 4-hydroxypyrimidin-2,5-diyl radical; or a pharmacologically acceptable salt thereof. The compounds exhibit anti-histaminic, anti-oedematous and anti-phlogistic activity.

REFERENCES:
patent: 3255196 (1966-06-01), Debarre et al.
patent: 4027028 (1977-05-01), Vincent et al.

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