N-(phenoxyalkyl)imidazoles as selective inhibitors of the thromb

Details N-(phenoxyalkyl)imidazoles as selective inhibitors of the thromb N-(phenoxyalkyl)imidazoles as selective inhibitors of the thromb

1985-03-21

1987-01-13

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514326, 514381, 514397, 514399, 544139, 546210, 548252, 548336, 548341, A61K 31535, C07D23360

Patent

active

046365001

ABSTRACT:
N-(mono or disubstituted Phenoxyalkyl)imidazoles and the pharmaceutically acceptable acid addition salts thereof are able to selectively inhibit the action of the thromboxane synthetase enzyme without significantly inhibiting the action of the prostacycline synthetase or cyclooxygenase enzymes and are thus useful in the treatment of ischaemic heart disease, stroke, transient ischaemic attack, thrombosis migraine and the vascular complications of diabetes.

REFERENCES:
patent: 3534061 (1970-10-01), Black
patent: 4078071 (1978-03-01), Walker
Moncada et al., Prostaglandins, vol. 13, pp. 611-618, (1977).
Needleman et al., Proc. Natl. Acad. Sci., USA, vol. 74, pp. 1716-1720, (1977).
Tai et al., Biochem. Biophys. Res. Commun., vol. 80, pp. 236-242, (1978).
Yoshimoto et al., Prostaglandins, vol. 16, pp. 529-540, (1978).

Affiliated with

Also associated with

Rating

N-(phenoxyalkyl)imidazoles as selective inhibitors of the thromb does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N-(phenoxyalkyl)imidazoles as selective inhibitors of the thromb, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-(phenoxyalkyl)imidazoles as selective inhibitors of the thromb will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2355904