Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-07-09
2000-04-25
Seaman, D. Margaret
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514315, 514423, 540529, 546245, 548530, A61K 3140, A61K 3144, A61K 3150
Patent
active
06054452&
ABSTRACT:
This invention relates to neurotrophic low molecular weight, small molecule N-oxides of heterocyclic esters, amides, thioesters, and ketones having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
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Burak Eric S.
Hamilton Gregory S.
Steiner Joseph P.
GPI Nil Holdings Inc.
Juneau Todd L.
Nath Gary M.
Seaman D. Margaret
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