N-oxides and derivatives of melphalan for treating diseased...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

Reexamination Certificate

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C562S452000, C564S013000

Reexamination Certificate

active

07399785

ABSTRACT:
This invention relates to compounds which are N-oxides and derivatives thereof, as well as their use to treat HIF related diseases. These compounds have the general formula set out below and are used to treat a variety of diseases associated with HIF:wherein R is an alkyl, aryl, arakyl or derivatives thereof such as CH3OCH2CH2—, CH3CH2OCH2CH2—, C6H5OCH2CH2—, C6H5CH2—, CH3(CH2)3OCH2CH2Cl; or any one of the following:

REFERENCES:
patent: 5602278 (1997-02-01), Kirkpatrick
Kirkpatrick et al., Anti-Cancer Drugs, 1994, 5:467-472.
Welsh et al., Molecular Cancer Therapeutics, 2004, 3(3): 233-244.
Welsh, Sarah J., et al.; PX-478—A Potent Inhibitor of Hypoxia-Inducible Factor-1 and Anti-Tumor Agent; Nov. 19-22, 2002 AACR-EORTC-NCI Meeting, Frankfurt, Germany.
{hacek over (Z)}algeviciene, Violeta, et al..; Embryotoxicity and teratogenicity of some derivatives of chloroethylaminophenylacetic acid; Pathology Oncology Research; vol. 4, No. 1, 1998; pp. 27-29.

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