Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-05-08
1997-10-21
Fonda, Kathleen K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 2, 514 8, 514 54, 536 20, 604 57, 424422, 424423, 424424, 424426, 424488, A61K 3173, C08B 3708, A61F 200
Patent
active
056796587
ABSTRACT:
The invention relates to a method of treating patients to minimize post-surgical adhesions and a kit useful in the method of the invention. The method is based on the timing that N,O-carboxymethylchitosan (NOCC) has advantageous properties as a wound healing lavage and coating. A NOCC solution is particularly effective as a post-surgical lavage and when used in conjunction with a NOCC gel coating, wound healing rate is unchanged while the number and severity of adhesions in greatly reduced.
REFERENCES:
patent: 4141973 (1979-02-01), Balazs
patent: 4619995 (1986-10-01), Hayas
patent: 4819617 (1989-04-01), Goldverg et al.
patent: 4886787 (1989-12-01), De Belder et al.
patent: 5023090 (1991-06-01), Levin
patent: 5080893 (1992-01-01), Goldberg et al.
patent: 5093319 (1992-03-01), Higham et al.
patent: 5140016 (1992-08-01), Goldberg et al.
patent: 5411988 (1995-05-01), Bockow et al.
patent: 5462990 (1995-10-01), Hubbell et al.
Buckman, R.F., et al. (1976) "A physiologic basis for the adhesion-free healing of deperitonealizing surfaces" J. Surg. Res. 21:67-76, months not available.
Elkins, T.E. et al. (1984) "Adhesion prevention by solutions of sodium carboxymethylcellulose in the rat. I." Fert. Ster. 41:926-928; months not available.
Elkins, T.E. et al. (1984) "Adhesion prevention by solutions of sodium carboxymethylcellulose in the rat. II." Fert. Ster. 41:929-932; months not available.
Fukasawa, M., et al. (1991) "Inhibition of postsurgical adhesions in a standarized rabbit model: II. Intraperitoneal treatment with heparin" Int. J. Fertil. 36:296-301; months not available.
Gervin, A.S. et al. (1973) "Serosal Hypofibrinolysis. A cause of postoperative adhesions" Am. J. Surg. 125:80-87; months not available.
Hemaheh, O. et al. (1993) "Prevention of peritoneal adhesion by administration of sodium carboxymethylcellulose and oral vitamin E." Surgery 114:907-910; months not available.
Holtz, G. (1980) "Prevention of posoperative adhesions" J. Rep. Med. 24:141-146; months not available.
Langford, M.P. (1995) "Effects on Healon, N,O Carboxymethyl Chitosan and Vitreon on Conjunctival Cells and Human Peripheral Blood Lymphocytes" Southern Biomedical Engineering Conference -Proceedings 1995 IEEE, Piscataway, NJ, USA (pp. 286-288), months not available.
Levinson, C.J. and Swolin, K. (1980) "Postoperative adhesions: Etiology, prevention and therapy" Clin. Obstet. Gynec. 23:1213-1220; months not available.
Nair, S.K. et al. (1974) "Role of proteolytic enzymes in the prevention of post-operative intraperitoneal adhesions." Arch. Surg. 108: 849-853; months not available.
Sahin Y. and Saglam A. (1994) "Synergistic effects of carboxymethylcellulose and low molecular weight heparin in reducing adhesion formation in the rat uterine horn model" Acta. Obstet. Gynecol. Scand. 73: 70-73; months not available.
Sawhaney et al. (1994) "Optimization of photopolymerized bioerodible bydrogel properties for adhesion prevention" J. Bio. Mat. Res. 28:831-838; months not available.
Thompson, J.N. et al. (1989) "Reduced human peritoneal plasminogen activating activity: Possible mechanism of adhesion formation" Br. J. Surg. 76:382-384; months not available.
Hirano et al. "Proc. Symp. Adv. Biomed. Polym." 1987, 285-297, months not available.
Muzzarelli Carbohydrate Polymers 1988(8), 1-21, months not available.
Chitogenics, Inc.
Fonda Kathleen K.
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