N,N′-substituted-1,3-diamino-2-hydroxypropane...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S649000, C564S297000, C564S300000

Reexamination Certificate

active

10291318

ABSTRACT:
Disclosed are compounds of the formulawherein the variables RN, RC, R1, R25, R2, and R3are as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of discorders such as Alzheimer's Disease.

REFERENCES:
patent: 4351842 (1982-09-01), Coles
patent: 4522811 (1985-06-01), Eppstein et al.
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5387742 (1995-02-01), Cordell
patent: 5559256 (1996-09-01), Gordon et al.
patent: 5593846 (1997-01-01), Schenk et al.
patent: 5604102 (1997-02-01), McConlogue et al.
patent: 5612486 (1997-03-01), McConlogue et al.
patent: 5720936 (1998-02-01), Wadsworth et al.
patent: 5721130 (1998-02-01), Seubert et al.
patent: 5744346 (1998-04-01), Chrysler et al.
patent: 5766846 (1998-06-01), Schlossmacher et al.
patent: 5811633 (1998-09-01), Wadsworth et al.
patent: 5850003 (1998-12-01), McLonlogue et al.
patent: 5877015 (1999-03-01), Hardy et al.
patent: 5877399 (1999-03-01), Hsiao et al.
patent: 5912410 (1999-06-01), Cordell
patent: 5942400 (1999-08-01), Anderson et al.
patent: 6045829 (2000-04-01), Liversidge et al.
patent: 0 652 009 (1995-05-01), None
patent: WO 98/22597 (1998-05-01), None
patent: WO 98/33795 (1998-08-01), None
patent: WO 00/03819 (2000-01-01), None
patent: WO 00/17369 (2000-03-01), None
patent: WO 00/47618 (2000-08-01), None
patent: WO 01/23533 (2001-02-01), None
patent: WO 01/64001 (2001-04-01), None
patent: WO 01/10387 (2001-08-01), None
patent: WO 02/02505 (2002-01-01), None
patent: WO 02/02512 (2002-01-01), None
patent: WO 02/02518 (2002-01-01), None
patent: WO 02/02520 (2002-01-01), None
patent: WO 02/14264 (2002-02-01), None
CAPLUS abstract of 1960:38832, Sicher, J. et al, “Amino acids adn peptides. XXVIII.” Collection of Czechoslovak Chemical Communications (1959). vol. 24, pp. 3719-3729.
CAPLUS abstract of 1999:684298, Lubisch, W. et al, “New substituted benzamides: preparation and application.” DE patent 19817461 A1 (1999).
Chevallier, et al., (1997) “Cathepsin D displays in vitro β-secretase-like specificity” Brain Research, 750: pp. 11-19.
B. Gisin, Helv. Chim. Acta 1970, vol. 53, 1030-1043.
Bennett, Frank. Synlett 1993, 703-704.
Burness, D.M.; J. Org. Chem., 1956, 21, 97.
Calderwood, et al., Tet. Lett., 1997, 38, 1241.
Cancer Research, 53, 4595-4602 (1993).
Cancer Research, 56, 4171-4179 (1996).
Chem. Rev. 1995, 95, 2457.
Ciganek, J. Org. Chem., 1992, 57, 4521.
Citron et al., 1992, Nature 360 :672-674.
Clin. Cancer Res., 2, 7-12 (1996).
Daves, G.D., O'Brien, D.E., Lewis, L. and Cheng, C.C.; J. Heterocycl. Chem., 1963, 1, 130.
Emilieu, 2000, Arch. Neurol. 57:454.
EW. Org. Synth. Coll. vol. II, 313-315.
Felman et al., J. Med. Chem., 1992, 35, 1183.
Felman, SW et al., J. Med. Chem. 1992, 35, 1183-1190.
G. Bold, J. Medicinal Chemistry 1998, vol. 41, 3387-3401.
Ganes et al., 1995, Nature 373 :523-527.
Hardy, 1992, Nature Genet. 1:233-234.
Heterocycles 32 (4), 693-701, (1991).
Hussain et al., 1999, Mol. Cell. Neurosci. 14 :419-427.
Int. J. Pharm., 33, 201-217 (1986).
J. Am. Chem. Soc. 1970, 92, 3700.
J. Am. Chem. Soc. 1978, 100, 3918.
J. Am. Chem. Soc. 1986, 3150.
J. Am. Chem. Soc., 60, 105 (1938).
J. Heterocyclic. Chem. 17, 1281 (1980).
J. Med. Chem. 1997, 40, 3997.
J. Med. Chem. 1998, 41, 1581.
J. Med. Chem. 1998, 41, 3782-3792.
J. Med. Chem., 1997, 40, 2323.
J. Med. Chem., 1999, 42, 4193.
J. Med. Chem., 36, 288-291 (1992).
J. Med. Chem., 38, 581-584 (1994).
J. Med. Chem., 4288 (2000).
J. Org. Chem. 2000, 65, 1305.
J. Pharm. Sci., 66(1), 1, (1977).
Kang et al., 1987, Nature 325 :733-6.
Kitaguchi et al., 1981, Nature 331 :530-532.
Klumpp, et al., J. Am. Chem. Soc., 1979, 101, 7065.
Kosugi and Migita, Bull. Chem. Soc., Jpn., 1987, 60, 767-768.
Larock, R.C. in Comprehensive Organic Transformations, VCH Publishers, 1989.
Lin et al., 2000, PNAS USA 97 :1456-1460.
Luo et. al., 2001 Nature Neuroscience 4 :231-232.
M. Nakakata, Tetrahedron Letters 1993, 6095-6098.
M.P. Doyle; M.A. McKervery; T. Ye in Modern Catalytic Methods for Organic Synthesis with Diazo Compounds from Cyclopropanes to Ylides, Wiley-Interscience, 1998, pp. 163-279.
Mashraqui, SH; Keehn, PM. J. Am. Chem. Soc. 1982, 104, 4461-4465.
Meyers, A.I., Org. Syn., 1971, 51, 103.
N.W. Werner et al., J. Org. Syn. Coll. vol. 5, 273-276.
Org. Lett. (2000) 1485.
Org. Lett. (2001) 1005.
Org. Prep. Proc. Int. 1995, 27, 355-9.
Org. Prep. Proceed. Intern. (1982) 396.
Palladium Reagents in Organic Synthesis, 1985 pp. 342-365.
Pirttila et al., 1999, Neuro. Lett. 249 :21-4.
Protecting Groups in Organic Chemistry, Plenum Press, New York, N.Y., 1973 Chapter 2, p. 43-93.
R.C. Larock in Comprehensive Organic Transformations, VCH Publishers, 1989, p. 313.
R.C. Larock in Comprehensive Organic Transformations, VCH Publishers, 1989, p. 981, 979 and 972.
S. Rosenberg, J. Medicinal Chemistry 1990, vol. 33, 1582-1590.
S. Wang, J. Medicinal Chemistry 1997, vol. 40, 937-941.
Sinha et al., 1999, Nature 40: 537-540.
Tet. Lett. (1995) 4005.
Tet. Lett. 2000, 41, 3271.
Tetrahedron Letters, 28, 5569-5572 (1987).
Tetrahedron Letters, 38, 619-620 (1997).
Tetrahedron, 50, 979-988 (1994).
Thurkauf, et al., J. Med. Chem., 1990, 33, 1452.
Vassar et al., 1999, Science 286: 735-741.
Wilk, BK. Synth. Commun. 1993, 23, 2481-4.
Yan et al., 1999, Nature 402: 533-537.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

N,N′-substituted-1,3-diamino-2-hydroxypropane... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N,N′-substituted-1,3-diamino-2-hydroxypropane..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N,N′-substituted-1,3-diamino-2-hydroxypropane... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3868808

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.