Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-10-12
2010-12-07
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S264110, C544S279000, C544S122000
Reexamination Certificate
active
07846927
ABSTRACT:
Compounds of the formula (I), in which R1, R3and X have the meanings indicated in Claim1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.
REFERENCES:
patent: WO 02/44156 (2002-06-01), None
patent: WO 2004/078747 (2004-09-01), None
Hodous, et al., J. Med. Chem., 2007, vol. 50, No. 4.
Oehler-Jänne, et al., Molec. Cancer Therap. 6, 2496-2504, Sep. 1, 2007.
Jechlinger, et al., J. Clin. Invest. 116(6): 1561-1570 (2006).
Fogarty, et al., PNAS Feb. 20, 2007 vol. 104 No. 8 2973-2978.
Talvensaari-Mattila, et al., Tumor Biol., vol. 26, No. 2, 2005 (Abstract).
Griesser, Chapter 8, The Importance of Solvates (pp. 211-230), in the text, Polymorphism: In the Pharmaceutical Industry, Hilfiker, 2006.
Wikipedia, (chemistry) derivatives downloaded Dec. 31, 2008.
Agrawal, et al., Endocrine-Related Cancer 12 (Suppl 1) S135-144, 2005.
Keller, Anti-Cancer Drugs, Aug. 2004, vol. 15, # 7, pp. 663-669.
J.-L. Girardet et al., Synthesis and Cytotoxicity of 4-Amino-5-oxopyrido [2,3-d]pyrimidine Nucleosides Journal of Medicinal Chemistry., Nr. 43, 2000, pp. 3704-3713.
Crassier Helene
Hoelzemann Guenter
Jonczyk Alfred
Rautenberg Wilfried
Jaisle Cecilia M
Merck Patent GmbH
Perkins Coie LLP
Wilson James O
LandOfFree
N,N′-diphenylurea derivatives suitable as kinase... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with N,N′-diphenylurea derivatives suitable as kinase..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N,N′-diphenylurea derivatives suitable as kinase... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4216562