N,N- substituted amines and use thereof in hair growth promotion

Details N,N- substituted amines and use thereof in hair growth promotion N,N- substituted amines and use thereof in hair growth promotion

1990-06-27

1992-08-11

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514252, 514253, 514254, 514255, 514257, 514258, 514262, 514267, 514277, 514299, 514315, 514332, 514333, 514359, 514408, 514422, 5142295, A01N 4358, A01N 4360, A61K 31495, A61K 3150

Patent

active

051378884

ABSTRACT:
Novel compounds are provided having the general formula RB.sub.n wherein R is a multi-functional amine moiety having at least n amine-functional nitrogen sites, n equals 2 to about 8, and B are disubstituted heterocyclic N-oxide moieties which are attached to amine functional nitrogen atoms of R, and each B is independently selected from the group consisting of pyridines, pyrimidines and triazines. These novel compounds and similar known compounds are useful in the promotion of hair growth by topical application to mammalian skins. Particularly preferred compounds of the invention are those in which the B moieties are disubstituted with amine groups adjacent the N-oxide position of the heterocyclic ring.

REFERENCES:
patent: 4139619 (1979-02-01), Chidsey, III
patent: 4596812 (1986-06-01), Chidsey, III
Catto et al. "2,4-Diamino-6-Piperidinil e 6-Piperazinilpirimidine 3-Ossido-, Nuovi Analoghi Del Minossidile" Boll. Chim. Farm. 121 (1982) pp. 16-26.

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