(+)-N-N-propylnorapomorphine and selective limbic activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514284, 546 48, 546 75, A61K 3147, C07D22118, C07D49106

Patent

active

046877738

ABSTRACT:
Antidopaminergic agents having selective limbic activity, comprising (S)-enantiomers of aporphine compounds of either the following structures: ##STR1## wherein R.sub.1 is lower alkyl, alkyl substituted lower alkyl, alkyl substituted cycloalkyl, lower alkenyl, alkyl substituted lower alkenyl, lower alkynyl, alkyl substituted lower alkynyl, phenyl lower alkyl, phenyl lower alkenyl, and phenyl lower alkynyl, and the following structure where R.sub.1 is above and R.sub.2 and R.sub.3 are hydrogen, methyl, or R.sub.1 ##STR2## R.sub.1 is as above R.sub.4 is H, CH.sub.3 lower alkyl, or R.sup.1 C0--where R.sup.1 =CH.sub.3 or lower alkyl.

REFERENCES:
patent: 3717639 (1973-02-01), Neumeyer
patent: 3717643 (1973-02-01), Archer
patent: 3810987 (1976-05-01), Saari
patent: 4353912 (1982-10-01), Neumeyer
patent: 4543256 (1985-09-01), Neumeyer
Ram et al., J. Org. Chem., vol. 46, pp. 2830-2831 (1981).
Campbell et al., Neuropharmacology, vol. 24, pp. 391-399 (1985).
Lal et al., Chemical Abstracts, vol. 78, 92509j (1973).
Sheppard et al., Chemical Abstracts, vol. 90, 116902j (1979).
Saari et al., J. Med. Chem., vol. 17, No. 10, pp. 1086-1090 (1974).
Neumeyer et al., J. Med. Chem., vol. 17, No. 10, pp. 1090-1095 (1974).
Baldessarini et al., Biochemical Pharmacology, vol. 26, pp. 1749-1756 (1977).
Davis et al., J. Pharm. Sci., vol. 69, No. 9, pp. 1056-1058 (1980).
Neumeyer et al., J. Med. Chem., vol. 24, No. 12, pp. 1440-1445 (1981).
Neumeyer et al., Abstracts of Papers, North American Medicinal Chemistry Symposium, University of Toronto, Toronto, Canada, p. 48, 6/82.
Neumeyer et al., J. Med. Chem., vol. 26, No. 4, pp. 516-521 (04/83).
Riffee et al., Chemical Abstracts, vol. 97, 85170f (1982).
Heikkila et al, Chemical Abstracts, vol. 98, 192339k (1983).
Baldessarini et al., Eur. J. Pharmacol., vol. 77, No. 1, pp. 87-88 (1982).
Hinsie et al., "Psychiatric Dictionary", Oxford University Press, New York (1970), pp. 619-620.
Costall et al., European J. Pharmacology, vol. 35, pp. 161-168 (1976).
American Psychiatric Association, "A Psychiatric Glossary" (1980), pp. 64, 123.
Coyle et al., ed., "Neuroleptics: Neurochemical, Behavioral, and Clinical Prospectives", Raven Press, New York (1983), pp. 1-2, 12, 93-117, 119, 150.
Karasu, ed., "The Psychiatric Therapies", American Psychiatric Association, Washington, D.C. (1984), pp. 119-120.
Goodman & Gilman's "The Pharmacological Basis of Therapeutics", 7th ed., Macmillan Pub. Co., New York (1985), pp. 339, 340, 387, 391.
Baldessarini, "Chemotherapy in Psychiatry", Harvard U. Press, Cambridge, Mass. (1985), pp. 14-15, 37-46, 235-236.
Campbell et al., Psychopharmacology, vol. 88, pp. 158-164 (1986).
Campbell et al., Brain Research, in press.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

(+)-N-N-propylnorapomorphine and selective limbic activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with (+)-N-N-propylnorapomorphine and selective limbic activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and (+)-N-N-propylnorapomorphine and selective limbic activity will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1118040

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.