(+)-N-N-propylnorapomorphine and selective limbic activity

Details (+)-N-N-propylnorapomorphine and selective limbic activity (+)-N-N-propylnorapomorphine and selective limbic activity

1985-05-31

1987-08-18

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514284, 546 48, 546 75, A61K 3147, C07D22118, C07D49106

Patent

active

046877738

ABSTRACT:
Antidopaminergic agents having selective limbic activity, comprising (S)-enantiomers of aporphine compounds of either the following structures: ##STR1## wherein R.sub.1 is lower alkyl, alkyl substituted lower alkyl, alkyl substituted cycloalkyl, lower alkenyl, alkyl substituted lower alkenyl, lower alkynyl, alkyl substituted lower alkynyl, phenyl lower alkyl, phenyl lower alkenyl, and phenyl lower alkynyl, and the following structure where R.sub.1 is above and R.sub.2 and R.sub.3 are hydrogen, methyl, or R.sub.1 ##STR2## R.sub.1 is as above R.sub.4 is H, CH.sub.3 lower alkyl, or R.sup.1 C0--where R.sup.1 =CH.sub.3 or lower alkyl.

REFERENCES:
patent: 3717639 (1973-02-01), Neumeyer
patent: 3717643 (1973-02-01), Archer
patent: 3810987 (1976-05-01), Saari
patent: 4353912 (1982-10-01), Neumeyer
patent: 4543256 (1985-09-01), Neumeyer
Ram et al., J. Org. Chem., vol. 46, pp. 2830-2831 (1981).
Campbell et al., Neuropharmacology, vol. 24, pp. 391-399 (1985).
Lal et al., Chemical Abstracts, vol. 78, 92509j (1973).
Sheppard et al., Chemical Abstracts, vol. 90, 116902j (1979).
Saari et al., J. Med. Chem., vol. 17, No. 10, pp. 1086-1090 (1974).
Neumeyer et al., J. Med. Chem., vol. 17, No. 10, pp. 1090-1095 (1974).
Baldessarini et al., Biochemical Pharmacology, vol. 26, pp. 1749-1756 (1977).
Davis et al., J. Pharm. Sci., vol. 69, No. 9, pp. 1056-1058 (1980).
Neumeyer et al., J. Med. Chem., vol. 24, No. 12, pp. 1440-1445 (1981).
Neumeyer et al., Abstracts of Papers, North American Medicinal Chemistry Symposium, University of Toronto, Toronto, Canada, p. 48, 6/82.
Neumeyer et al., J. Med. Chem., vol. 26, No. 4, pp. 516-521 (04/83).
Riffee et al., Chemical Abstracts, vol. 97, 85170f (1982).
Heikkila et al, Chemical Abstracts, vol. 98, 192339k (1983).
Baldessarini et al., Eur. J. Pharmacol., vol. 77, No. 1, pp. 87-88 (1982).
Hinsie et al., "Psychiatric Dictionary", Oxford University Press, New York (1970), pp. 619-620.
Costall et al., European J. Pharmacology, vol. 35, pp. 161-168 (1976).
American Psychiatric Association, "A Psychiatric Glossary" (1980), pp. 64, 123.
Coyle et al., ed., "Neuroleptics: Neurochemical, Behavioral, and Clinical Prospectives", Raven Press, New York (1983), pp. 1-2, 12, 93-117, 119, 150.
Karasu, ed., "The Psychiatric Therapies", American Psychiatric Association, Washington, D.C. (1984), pp. 119-120.
Goodman & Gilman's "The Pharmacological Basis of Therapeutics", 7th ed., Macmillan Pub. Co., New York (1985), pp. 339, 340, 387, 391.
Baldessarini, "Chemotherapy in Psychiatry", Harvard U. Press, Cambridge, Mass. (1985), pp. 14-15, 37-46, 235-236.
Campbell et al., Psychopharmacology, vol. 88, pp. 158-164 (1986).
Campbell et al., Brain Research, in press.

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