N,N-pentamethylene derivatives of daunomycin and adriamycin

Details N,N-pentamethylene derivatives of daunomycin and adriamycin N,N-pentamethylene derivatives of daunomycin and adriamycin

1978-10-02

1980-05-13

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, C07H 1524

Patent

active

042029678

ABSTRACT:
Described are N,N-pentamethylene derivatives of daunomycin and adriamycin having the formula: ##STR1## wherein R.sup.1 is --COCH.sub.3 or --CHOHCH.sub.3 in the case of daunomycin derivatives, or --COCH.sub.2 OH or --CHOHCH.sub.2 OH in the case of adriamycin derivatives. The compounds have utility as antitumor agents.

REFERENCES:
patent: 4039736 (1977-08-01), Nettleton et al.
Henry et al., "Abstract of Papers 172nd ACS Meeting, Amer. Chem. Soc.", San Francisco, Calif. 8/29-9/3/76, Port City Press, Inc., Baltimore, Md., #90.
Zbinden, "Toxicology Letters", No. 1, 1978, pp. 267-274, Elsevier North-Holland Biomedical Press.

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