N,N',N'-trisubstituted-5-bisaminomethylene-1,3-dioxane-4,6-dione

Details N,N',N'-trisubstituted-5-bisaminomethylene-1,3-dioxane-4,6-dione N,N',N'-trisubstituted-5-bisaminomethylene-1,3-dioxane-4,6-dione

1992-12-30

1994-01-25

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546159, 546160, 546171, 546174, 548194, 548182, 548183, 5483111, 5483047, 544374, 544148, 544329, C07D40512

Patent

active

052817148

ABSTRACT:
The compounds of the formula: ##STR1## in which X, Y and Z are, independently, hydrogen, halogen, hydroxy, nitro, cyano, carboxyl, trifluoromethyl, phenyl, amino, alkylamino, dialkylamino, alkyl, alkoxy or phenylalkyloxy; R.sub.1 is thienyl, imidazolyl, thiazolyl, pyridinyl, quinolinyl, pyrimidinyl, pyrazinyl, benzamidazolyl, phenylalkylpiperidinyl or morpholino or athaae analogous hetercyclic groups with from one to tahree substituents selected from halogen, hydroxy, nitro, cyano, carboxyl, trifluoromethyl, phenyl, amino, alkylamino of 1 to 6 carbon atoms, dialkylamino in which each alkyl group has 1 to 6 carbon atoms, alkyl of 1 to 6 carbon atoms, or alkoxy of 1 to 6 carbon atoms; R.sub.2 is hydrogen, alkyl, cycloalkyl, phenyl, benzyl or substituted phenyl or benzyl in which said substituent is alkyl, alkoxy, halogen, cyano, trifluoromethyl amino, nitro, alkylamino or dialkylamino; and a pharmaceutically acceptable salt thereof; are ACAT inhibitors, some of which possess antioxidant properties.

REFERENCES:
patent: 4387105 (1983-06-01), DeVries et al.
patent: 4387106 (1983-06-01), DeVries et al.
Augustin et al. CA 113: 231288t, 1990.
J. Med. Chem. 29, 1131 (1986), De Vries et al.
Stephen, Monat. Fur Chemie, 97, 45 (1966).
Derwent Abstract 40365K.

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