N,N',N'-trisubstituted-5-bis-aminomethylene-1,3-dioxane-4,6-dion

Details N,N',N'-trisubstituted-5-bis-aminomethylene-1,3-dioxane-4,6-dion N,N',N'-trisubstituted-5-bis-aminomethylene-1,3-dioxane-4,6-dion

1991-09-06

1992-08-04

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546153, 546155, 546160, A61K 3147, C07D27782

Patent

active

051360390

ABSTRACT:
A compound of the formula: ##STR1## in which X, Y and Z are, independently, hydrogen, halogen, hydroxy, nitro, cyano, carboxyl, trifluoromethyl, phenyl, amino, alkylamino, dialkylamino, alkyl or alkoxy; R.sub.1 is alkyl, alkenyl, cycloalkyl, phenyl, benzyl or substituted phenyl or benzyl or alkoxy; R.sub.2 is: ##STR2## or a pharmaceutically acceptable salt thereof, are ACAT inhibitors.

REFERENCES:
patent: 4387105 (1983-06-01), DeVries et al.
patent: 4387106 (1983-06-01), DeVries et al.
DeVries et al., J. Med. Chem., 29, 1131-3 (1986).
Stephen, Monatsche Fur Chemie, 97, p. 45 and pp. 696-702 (1966).
Derwent Abstract 40365k of Japanese J58046084 Sep. 14, 1981.
Augustin et al, Z. Chem. 30, 169-70 (1990).

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