Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1995-06-06
1996-09-24
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514357, 514471, 514438, 514415, 514427, 514522, 514601, 514604, 514605, 546338, 549 75, 549491, 548503, 548507, 548561, 562430, 564 82, 558394, A61K 3119, C07C31726, C07C31121, C07D21342
Patent
active
055591507
ABSTRACT:
The present invention is directed to novel compounds that are non-peptidic thrombin inhibitors. The compounds have the structure: ##STR1## and pharmaceutically acceptable salts thereof; wherein R.sup.1 is one of alkyl, substituted alkyl, cycloalkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl; and n is from zero to five. The compounds of the invention are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and neurodegenerative diseases.
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Harker L. A., Strategies for inhibiting the effects of thrombin, Blood Coagulation and Fibrinolysis 5 (Suppl 1):S47-S58 (Jan. 1994).
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3-Dimensional Pharmaceuticals Inc.
Richter Johann
Stockton Laura L.
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