N,N'-disubstituted halophenylacetamidines

Details N,N'-disubstituted halophenylacetamidines N,N'-disubstituted halophenylacetamidines

1976-02-11

1977-06-14

Schwartz, Gerald A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26050114, 424316, 424326, C07C12300

Patent

active

040297039

ABSTRACT:
N,N'-Disubstituted halophenylacetamidine compounds such as N,N'-dimethyl-3,4-dichlorophenyl-acetamidine, and their pharmaceutically-acceptable salts are prepared by the reaction of a substituted phenylacetonitrile with an alkylamine and alkylammonium salt or alternatively, by reaction of the acetonitrile or corresponding N-alkylphenylacetamide with a trialkyloxonium fluoroborate followed by reaction with a primary alkylamine.The compounds have pharmacological activity as antidepressants and antianxiety or calming agents.

REFERENCES:
chemical Abstracts, vol. 59, col. 11522(g), (1963).
Chemical Abstracts, vol. 65, col. 2181(c), (1966).
Chemical Abstracts, vol. 64, col. 17, 499(f), (1966).

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