Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-07-04
2006-07-04
Bernhardt, Emily (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S394000, C540S575000, C514S218000
Reexamination Certificate
active
07071197
ABSTRACT:
N,N-Disubstituted diazocycloalkanes of the formula I(R1=halogen, R2=(C3–C8)-cycloalkyl, R3=(C1–C4)-alkoxy or (C1–C4)-haloalkoxy group, m is 1 or 2 and n is 1 or 2, have affinity for serotonergic receptors. These compounds and their enantiomers, diastereoisomers, N-oxides, polymorphs, solvates and pharmaceutically acceptable salts are useful in the treatment of patients with neuromuscular dysfunction of the lower urinary tract and diseases related to 5-HT1Areceptor.
REFERENCES:
patent: 4122176 (1978-10-01), Katsube et al.
patent: 4217349 (1980-08-01), Katsube et al.
patent: 5340812 (1994-08-01), Cliffe
patent: 5346896 (1994-09-01), Ward et al.
patent: 5462934 (1995-10-01), Goto et al.
patent: 5627177 (1997-05-01), Cliffe et al.
patent: 5693642 (1997-12-01), Cliffe et al.
patent: 5798362 (1998-08-01), Leonardi et al.
patent: 6239135 (2001-05-01), Kohlman et al.
patent: 6306861 (2001-10-01), Leonardi et al.
patent: 6365591 (2001-10-01), Leonardi et al.
patent: 6358958 (2002-03-01), Kohlman et al.
patent: 6403594 (2002-06-01), Leonardi et al.
patent: 6514976 (2003-02-01), Kohlman et al.
patent: 2001/0003749 (2001-06-01), Godfrey et al.
patent: 642084 (1964-07-01), None
patent: 0 605 230 (1994-07-01), None
patent: 0 924 205 (1999-06-01), None
patent: 2 527 605 (1983-12-01), None
patent: WO 92/06082 (1992-04-01), None
patent: WO 94/15919 (1994-07-01), None
patent: WO 99/06382 (1999-02-01), None
patent: WO 99/06383 (1999-02-01), None
patent: WO 99/31077 (1999-06-01), None
patent: 03/106443 (2003-12-01), None
Testa et al. BJU International, vol. 87, p. 256-264 (Feb. 2001).
Vippagunta et al. Advanced Drug Delivery Reviews, vol. 48, p. 3-26 (2001).
Olivier et al. Medline Abstract for Prog. Drug Res. vol. 52, p. 103-165 (1999).
Abdel-Magid, A. et al., (1996) Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures,J. Org. Chem., 61:3849-3862.
Andersson K-E, (1988) Current Concepts in the Treatment of Disorders of Micturition,Practical Therapeutics, 35:477-494.
Bliss C.I., (1938) The Determination of the Dosage-Mortality Curve from Small Numbers,Quart. J. Pharm., 11:192-216.
Brougham et al., (1987) Oxidation Reactions Using Magnesium Monoperphthalate: A Comparison with m-Chloroperoxybenzoic Acid,Synthesis, 1015-1017.
Cheng et al., (1973) Relationship Between the Inhibition Constant (K1) and the Concentration of Inhibitor which causes 50 percent Inhibition (I50) of an Enzymatic Reaction,Biochemical Pharmacology, 22:3099-3108.
De Groat, (1990) Central neural control of the lower urinary tract,Neurobiol. Of Incontinence, Ciba Found. Symp., 151:27-56.
De Lean A. et al., (1978) Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves,Am. J. Physiol., 235:E97-E102.
Dray A., (1985) The Rat Urinary Bladder, A Novel Preparation for the Investigation of Central Opioid Activity In Vivo, J. of Pharm. Methods, 13:157-165.
Fargin A. et al., (1988) The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor,Nature, 335:358-360.
Felluga et al., (1989) “Carbo- and Heterocyclization Reactions of 2-(4-Morpholinyl)-1-Phenylpropene and Nitroolefins”,Tetrahedron, 45:5667-5678.
Goodman & Gilman, (1996) The Pharmacological Basis of Therapeutics 9thEd., McGraw-Hill p. 11-17.
Guarneri L. et a., (1993) Effects of Drugs Used in the Therapy of Detrusor Hyperactivity on the Volume-Induced Contraction of the Rat Urinary Bladder,Pharmacological Research, 27:173-187.
Guarneri L. et al., (1991) Effects of Different Drugs on the Cystometrogram in Conscious Rats,Pharmacological Research, 24:175-187.
Guarneri L. et al., (1994) A Review of Flavoxate: Pharmacology and Mechanism of Action,Drugs of Today, 30:91-98.
Lepor et al., (1993) “Medical Therapy for Benign Prostatic Hyperplasia”,Urology, 42:483-501.
Maggi C.A. et al., (1984) Evidence for the Involvement of Arachidonic Acid Metabolites in Spontaneous and Drug-induced Contractions of Rat Urinary Bladder,J. of Pharm. And Experimental Therapeutics, 230:500-513.
Maggi C.A. et al., (1986) Somatovesical and Vesicovesical Excitatory Reflexes in Urethane-Anaesthetized Rats,Brain Research, 380:83-93.
March J., (1977) Oxidation or Dehydrogenation of Alcohols to Aldehydes and Ketones,Advanced Organic Chemistry II Ed., McGraw-Hill, 1082-1084.
March J., (1977) Ozonolysis; Oxidative Cleavage of Double Bonds,Advanced Organic Chemistry II Ed., McGraw-Hill, 1090-1096.
March J., (1977) The Addition of Organometallic Compounds to Aldehydes and Ketones,Advanced Organic Chemistry II Ed., McGraw-Hill, 836-841.
Marx M. et al., (1984) Reactivity-Selectivity in the Swern Oxidation of Alcohols Using Dimethyl Sulfoxide-Oxalyl Chloride,J. Org. Chem., 49:788-793.
McGuire E., (1986) Neuromuscular Dysfunction of the Lower Urinary Tract,Campbell's Urology, 1:616-638.
Nagata et al., (1970) “Hydrocyanation. Part IX. Synthesis of β-Cyano-aldehydes by Conjugate Hydrocyanation of Allylideneamines Followed by Hydrolysis”,J. Chem. Soc.(C), pp. 2355-2364.
Nahm S. et al., (1981) N-methoxy-N-methylamides as Effective Acylating Agents,Tetrahedron Letters, 22:3815-3818.
Nilvebrant L., (2001) Clinical experiences with tolterodine,Life Sciences, 68:2549-2556.
Ruffmann R., (1988) A Review of Flavoxate Hydrochloride in the Treatment of Urge Incontinence,J. of International Medical Research, 16:317-330.
Tricklebank M.D. et al., (1985) Subtypes of the 5-HT Receptor Mediating the Behavioural Responses to 5-Methoxy-N, N-dimethyltryptamine in the Rat,European J. of Pharmacology, 117:15-24.
Crossfire Beilstein online database Jun. 29, 1989 Beilstein Institut zur Forderung der Chemischen Wissenschaften, Frankfurt am Main, DE; Database accession No. 2087440.
Crossfire Beilstein online database Aug. 28, 1992 Beilstein Institut zur Forderung der Chemischen Wissenschaften, Frankfurt am Main, DE; Database accession No. 5019111.
Forbes et al., (1980) “Applications of Substituted Arylacetaldehydes in the Total Synthesis of seco-Mesembrane Alkaloids. Part 1. The Total Synthesis of (‡-O-Methyljoubertiamine”,J.C.S. Perkins I, p. 906-910.
Vasileva et al., (1991) “Synthesis and biological activity of α-phenyl-β-(1-alkylaryl-4-piperazinyl)propiophenones”,Dokl. Bulg. Akad. Nauk., 44:55-58.
Natova et al., (1978) “Structure of some Mannich bases”,God. Vissh. Khim.-Tekhnol. Isnt., Sofia, 24:37-46.
Leonardi Amedeo
Motta Gianni
Riva Carlo
Testa Rodolfo
Bernhardt Emily
Recordati S.A.
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