N,N-disubstituted derivatives of 3-carboxamide or 3-thiocarboxam

Details N,N-disubstituted derivatives of 3-carboxamide or 3-thiocarboxam N,N-disubstituted derivatives of 3-carboxamide or 3-thiocarboxam

1976-11-11

1977-09-13

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

424249, C07D25710, C07D51900

Patent

active

040481670

ABSTRACT:
Compounds of the formula ##STR1## where X represents O or S and R.sub.1 and R.sub.2 each represents lower alkyl, phenyl or (lower alkyl)phenyl. The compounds are prepared by reacting the ring-opened intermediate (obtained by reacting cis-1-(3-chloro-2-propenyl)-3,5,7-triaza-1-azoniatricyclo(3.3.1.1.sup.3,7) decane chloride with excess aqueous sodium hydroxide) with an equivalent amount of a corresponding carbamoyl halide or thiocarbamoyl halide or at a low temperature to give the indicated tetrasubstituted urea or thiourea product. The compounds have antimicrobial utility.

REFERENCES:
patent: 3862187 (1975-01-01), Mitchell et al.

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