N,N'-Disubstituted benzamidines

Details N,N'-Disubstituted benzamidines N,N'-Disubstituted benzamidines

1974-11-29

1976-08-03

Schwartz, Gerald A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26050114, 424316, 424326, C07C12300

Patent

active

039729311

ABSTRACT:
N,N'-Disubstituted benzamidine compounds such as N,N'-dimethyl-3,4-dichlorobenzamidine, and their pharmaceutically-acceptable salts are prepared by the reaction of a substituted phenylacetonitrile with an alkylamine and alkylammonium salt or alternatively, by reaction of the acetonitrile or corresponding N-alkylphenylacetamide with a trialkyloxonium fluoroborate followed by reaction with a primary alkylamine. The compounds have pharmacological activity as antidepressants and antianxiety or calming agents.

REFERENCES:
patent: 3792057 (1974-02-01), Jensen et al.
Chem. Abstr., vol. 71, Col. 111,086(t) (1969).
Chem. Abstr., vol. 71, Col. 123,763(z) (1969).

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