Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-03-25
1999-07-06
Gupta, Yogendra N.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514350, 514355, 514364, 514365, 514371, 514372, 514374, 514378, 514406, 514427, 514444, 514465, 514471, 514533, 514539, 514570, 514332, 544332, 546290, 546309, 548204, 548214, 548235, 548247, 5483381, 548571, 548572, 549 58, 549435, 549487, 560 21, 562443, 562444, 562449, 562450, A61K 31505, A61K 3144, C07D23926, C07D21302
Patent
active
059197862
ABSTRACT:
The present invention relates to a compound of the formula (I): ##STR1## wherein Ar.sup.1, Ar.sup.2, Ar.sup.3 and Ar.sup.4 represent an aryl group or a heteroaromatic ring group; A represents a hydrocarbon group which may be substituted; X and Y represent an oxygen atom, a sulfur atom, a carbonyl group or a group of the formula --CHR.sup.a -- (wherein R.sup.a is a hydrogen atom or a lower alkyl group) or --NR.sup.b -- (wherein R.sup.b is a hydrogen atom or a lower alkyl group), or X and Y together represent a vinylene group or an ethynylene group; R.sup.1, R.sup.2, R.sup.3, R.sup.8 and R.sup.9 represent a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a lower alkoxy group; R.sup.4 and R.sup.5 represent a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, a nitro group, a cyano group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a lower alkyl group, a lower hydroxyalkyl group, a lower fluoroalkyl group or a lower alkoxy group, R.sup.6 is a lower alkyl group, and R.sup.7 is a hydrogen atom or a lower alkyl group, provided that when one of X and Y is an oxygen atom, a sulfur atom or a group of the formula --NR.sup.b --, the other is a carbonyl group or a group of the formula --CHR.sup.a --, its pharmaceutically acceptable salt or ester, and an antitumor agent containing it as an active ingredient.
REFERENCES:
patent: 5260465 (1993-11-01), Singh et al.
patent: 5340828 (1994-08-01), Graham et al.
patent: 5488149 (1996-01-01), Nomoto et al.
Aoyama Tetsuya
Arai Sachie
Iwasawa Yoshikazu
Kawakami Kumiko
Monden Yoshiaki
Banyu Pharmaceutical Co. Ltd.
Gupta Yogendra N.
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