N,N-disubstituted amic acid derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514350, 514355, 514364, 514365, 514371, 514372, 514374, 514378, 514406, 514427, 514444, 514465, 514471, 514533, 514539, 514570, 514332, 544332, 546290, 546309, 548204, 548214, 548235, 548247, 5483381, 548571, 548572, 549 58, 549435, 549487, 560 21, 562443, 562444, 562449, 562450, A61K 31505, A61K 3144, C07D23926, C07D21302

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active

059197862

ABSTRACT:
The present invention relates to a compound of the formula (I): ##STR1## wherein Ar.sup.1, Ar.sup.2, Ar.sup.3 and Ar.sup.4 represent an aryl group or a heteroaromatic ring group; A represents a hydrocarbon group which may be substituted; X and Y represent an oxygen atom, a sulfur atom, a carbonyl group or a group of the formula --CHR.sup.a -- (wherein R.sup.a is a hydrogen atom or a lower alkyl group) or --NR.sup.b -- (wherein R.sup.b is a hydrogen atom or a lower alkyl group), or X and Y together represent a vinylene group or an ethynylene group; R.sup.1, R.sup.2, R.sup.3, R.sup.8 and R.sup.9 represent a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a lower alkoxy group; R.sup.4 and R.sup.5 represent a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, a nitro group, a cyano group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a lower alkyl group, a lower hydroxyalkyl group, a lower fluoroalkyl group or a lower alkoxy group, R.sup.6 is a lower alkyl group, and R.sup.7 is a hydrogen atom or a lower alkyl group, provided that when one of X and Y is an oxygen atom, a sulfur atom or a group of the formula --NR.sup.b --, the other is a carbonyl group or a group of the formula --CHR.sup.a --, its pharmaceutically acceptable salt or ester, and an antitumor agent containing it as an active ingredient.

REFERENCES:
patent: 5260465 (1993-11-01), Singh et al.
patent: 5340828 (1994-08-01), Graham et al.
patent: 5488149 (1996-01-01), Nomoto et al.

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